The drug colchicine was formerly used to treat gout.

Answer both in details.

The drug colchicine was formerly used to treat gout. Now, other drugs with a similar function are being considered for the treatment of cancer. What cytoskeletal component do colchicines affect, and why would drugs that target this component be effective at treating cancer? (5 marks)

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Tetracycline is an effective antibiotic because it inhibits protein synthesis. The action mechanism is binding the 30s ribosomal subunit in bacteria, thereby preventing the docking of amino-acylated tRNA. With your knowledge of the translation process, explain how tetracycline would prevent protein synthesis. (5 marks)

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ANSWER 1 Colchicine is a mitotic inhibitor. It prevents polymerisation of microtubules. Colchicine binds to tubulin which are monomers of microtubules. Colchicine binding to tubulin prevents thei...

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