Mr. F, age 46 years, has a history of persistent, unproductive cough for several months that has not responded to cough medication. He also has fatigue and anorexia. A diagnosis was made of active TB infection in the lower lobe of the right lung. He was prescribed antitubercular drugs and his family was scheduled for testing and prophylactic medication. What is the difficulty of early TB diagnosis? What are the reasons for the development of active infection? What is the preferred treatment? What is the mode of transmission of the microbe?
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